After conquering major cities of Iran, Alexander tries to conquer India, which later returned to Babylon because of the fatigue of his armies, and announce Babylonia as the eastern capital of Iran. Alexander began marrying Persian elders to validate his rule But during these actions he got a fever and died after 12 years and 8 months of his kingdom while he was 33.
After Alexander, there were occurred conflicts between the claimants of the kingdom until Egypt reached Ptolemy, Asia minor to Lysimachus, Macedonia and Greek to Cassander, and finally Iran and Mesopotamia reached Seleucus. From 311 to 304 BC, Seleucus defeated all his opponents and was crowned in 304 BC, and a Seleucid Empire was established by him that they called Seleucids, which ruled in a part of Achaemenid Empire lands until 65 BC.
The kings of the Seleucid dynasty began to emigrate the Greeks to Iran and spread them throughout their empire. The Seleucid dynasty also built new cities, including Silifke and Antioch, to resettle immigrants to consolidate their rule in Iran. The Seleucid Empire architecture and urbanization can be considered as the most important action of the Seleucids art on Iran. Eventually, with the rise of the Parthian government, the dominated territories of the Seleucid Empire came one after the other to capture the Parthians until 247 BC, on year all Achaemenid Empire cities in Iran conquered by Parthians, and the Seleucid empire collapsed after 65 years.